In many applications, interest focuses on assessing the relationship between a predictor and a multivariate outcome variable, and there may be prior knowledge about the shape of the regression curves.

In certain genetic studies, clinicians and genetic counselors are interested in estimating the cumulative risk of a disease for individuals with and without a rare deleterious mutation. Estimating the ...

Nonparametric estimation under shape constraints represents a vibrant field that bridges rigorous mathematical theory with practical applications. This approach leverages inherent qualitative ...