Discovering and bringing a new drug to market typically takes 14 years and costs approximately $ 2 billion USD. Today, the competitive landscape throughout the drug development process requires ...

In a study posted to the bioRxiv* preprint server, researchers studied the preclinical pharmacokinetics (PK) and in vitro absorption, distribution, metabolism, and elimination (ADME) properties of ...

A comprehensive overview of pharmacokinetics principles can be found in Chapter 5 of the widely used therapeutics textbook Pharmacotherapy: A Pathophysiologic Approach, 6th edition. [1] In addition, ...

The pharmacokinetics of trimethoprim (TMP) and sulfamethoxazole (SMZ) were studied in subjects with normal and impaired renal function after single doses of the drugs administered separately and in ...

Renal drug excretion involves filtration, reabsorption, and secretion, crucial for drug clearance and minimizing toxicity. The study models renal clearance using pharmacokinetic parameters, validated ...

Pharmacokinetic drug-drug interactions (DDIs) involving opioid analgesics can be problematic. Opioids are widely used, have a narrow therapeutic index, and can be associated with severe toxicity. The ...

Though studies evaluating the effects of posture on the absorption of drugs have been conducted, a systematized review revealed critical gaps in methodology. Of 18 original research articles selected ...