A comprehensive review article titled “Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses,” published in Quantitative Biology, ...

Co-first author Jiyuan Yang, PhD, St. Jude Department of Computational Biology and co-senior and corresponding author Jiyang Yu, PhD, St. Jude Department of Computational Biology interim chair look at ...

Immune low-response states significantly impact the effectiveness of immunotherapy in cancer treatment. These states ...

Spatial transcriptomics is a technique that provides information about gene expression patterns within intact tissues. This technology employs various methodologies, including in situ sequencing (ISS) ...

Not so long ago, the omics field was a highly siloed collection of specialized applications and technologies. Now, multiomics is going mainstream. But as researchers revel in single cell resolution, ...

RNA sequencing (RNA-seq) is a powerful tool in diagnosing Mendelian disorders, but the optimized sequencing depth for this technology has not yet been determined. In a new study published in the ...

Traditional analytical approaches often fail to uncover the complexities of biological systems involving many biomolecules. In contrast, omics, an interdisciplinary approach, focuses on understanding ...

Rapid advances in sequencing technologies have transformed our ability to diagnose human genetic disorders, yet many patients still lack a molecular ...