The first-in-human Phase 1 clinical study will evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamic profile of ENX-104 in healthy volunteers SAN DIEGO, Sept. 18, 2024 (GLOBE ...

The caudate nucleus (green) is a subcortical brain region located in the striatum. The striatum is one of several neural structures that make up the basal ganglia (colored regions) located below the ...

Generations of studying the root cause of schizophrenia have largely converged around a single theory: the “dopamine hypothesis,” which postulates that a combination of genetic susceptibility, ...

Every Halloween, my husband and I have the same hallowed tradition—we make a pumpkin pie and we watch a horror movie. And every year, two things are guaranteed to happen: I will remember that I don’t ...

The dopamine D2 receptor has two splice variants, D2S (Short) and D2L (Long). In dopamine neurons, both variants can act as autoreceptors to regulate neuronal excitability and dopamine release, but ...

Recent studies have used conditional knockout mice to selectively delete the D2 autoreceptor; however, these approaches result in global deletion of D2 autoreceptors early in development. The present ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, No. 17 (Aug. 16, 1994), pp. 8297-8301 (5 pages) The tone and regulation of the brain dopaminergic projections ...

Department of Dental Anesthesiology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan The intravenous anesthetic propofol is frequently used in general anesthesia and intravenous sedation.

D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as ...

A prominent aspect of drug addiction is the ability of drug-associated cues to elicit craving and facilitate relapse. Understanding the factors that regulate cue reactivity will be vital for improving ...

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